The School of Greatness
The School of Greatness

6 Ways To Optimize Your Hormone Health & Why It Matters EP 1315

Dr. Gillett is a dual-board Certified MD in Obesity Medicine and Family Medicine. His practice includes preventative medicine, aesthetics, sports medicine, hormone optimization, obstetrics and infertility, integrative medicine, and precision medicine including genomics.

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Lewis Howes Host

Topics Discussed

Episode Summary

Executive Summary: The episode argues that optimal hormone health is inseparable from overall lifestyle: exercise, diet, sleep, stress, sunlight/outdoor time, and spiritual/meaningful well-being. Dr. Kyle Gillette explains how metabolic syndrome, low protein intake, inactivity, poor sleep, alcohol, and processed foods disrupt hormones, while practical tools like fiber, protein, omega-3s, meal timing, and resistance training can improve body composition, fertility, and long-term health.

Main Topics: The six pillars of hormone and health optimization (Priority: 5/5): Dr. Gillette frames health as a system built on exercise, diet, sleep, stress, sunlight, and spirit; if one pillar is off, hormone function and well-being decline. Spirituality, meaning, and end-of-life care (Priority: 4/5): He describes how patients facing terminal illness often seek chaplains, pastors, or spiritual conversations, showing that meaning-making becomes central when health deteriorates. Hormone testing and feedback loops (Priority: 5/5): The discussion covers major hormone classes, biofeedback signs of healthy hormones, and how hormones influence each other through negative and positive feedback. Nutrition for hormone health (Priority: 5/5): Gillette recommends fiber, protein, omega-3s, nutrient timing, and avoiding alcohol as the most useful food-related strategies to support hormones and metabolic health. Metabolic syndrome, obesity, and prediabetes (Priority: 5/5): The episode links processed foods, inactivity, and indoor living to widespread insulin resistance and metabolic syndrome, emphasizing screening and early intervention. Exercise, muscle preservation, and weight loss (Priority: 4/5): He stresses resistance training, movement habits, and preserving lean mass, arguing that sustainable fat loss depends more on lifestyle patterns than short-term dieting. Supplements and clinical tools (Priority: 3/5): Creatine, L-carnitine, and glutathione precursors are presented as adjuncts, but only after core lifestyle changes and individualized care are addressed.

Key Arguments: Hormone dysfunction is usually downstream of broader lifestyle failure, especially metabolic syndrome. A healthy body cannot be sustained if diet, sleep, stress, exercise, sunlight, or spirituality are chronically misaligned. Spiritual distress can affect the whole household and may worsen physical and mental health. Hormone health is often best inferred from biofeedback such as energy, libido, mood, motivation, and body composition, but blood testing is needed when symptoms appear. Fiber is the most neglected nutrient category, with only a small minority of Americans getting enough. Protein intake is foundational because many hormone-related molecules and neurotransmitters derive from amino acids. Diet and exercise are the two most important levers for hormone health, with exercise acting more acutely and diet more structurally. Alcohol has no physiological health benefit and can worsen brain, gut, caloric balance, and hormonal function. Sustainable weight loss requires a caloric deficit, but the best interventions vary by patient; some need counting, meal timing, eating speed changes, or medication support. Skipping dinner or avoiding late-night eating can be useful for health, but meal omission alone is not a guaranteed weight-loss strategy. Women often need more resistance training and protein to preserve lean mass during weight loss, while men often need more attention to fiber, hydration, and cardiovascular movement. A movement habit that lasts a lifetime is more important than short bursts of intense exercise or extreme diets.

Data Points: Lifestyle pillars: 6 - Exercise, diet, sleep, stress, sunlight, and spirit are presented as the core health framework. Americans getting enough fiber: 5% - Dr. Gillette says only a small percentage of Americans consume enough healthy fiber. Recommended sleep duration: 7 to 8 hours per night - He describes this as an important target for both sleep quantity and quality. Protein intake example: Almost 1 gram per pound of body weight per day - He says this is his personal intake level, noting it is very high for most people. Body weight mentioned: 200 pounds - His approximate body weight when discussing protein intake and personal nutrition. Red meat frequency: 2 to 3 times per week - He says he eats red meat, but not daily. Red meat share of weekly protein: 5% to 10% - He estimates red meat makes up a small portion of his total protein intake. Alcohol guideline: 2 to 3 times per month - He suggests limiting alcohol to this frequency for the average person. Pre-diabetes prevalence: 40% to 50% of Americans - He describes metabolic syndrome/prediabetes as extremely common and often undiagnosed. Metabolically healthy Americans: About 7% - He cites a study indicating very few Americans met metabolic-health criteria under multiple markers. Glucose threshold for fasting concern: Over 100 fasting blood glucose - He mentions this as one screening indicator, while noting A1C and glucose tolerance testing are better. Healthy People 2030 goal: Reduce prediabetes prevalence from 40% to 34% - He references a national goal to improve screening and treatment. Weekly caloric beverage limit after weight loss: No more than 2 caloric beverages per month - He describes this as part of how he personally lost 40 pounds after his first child. Weight lost after first child: 40 pounds - He says he lost this amount by eliminating liquid calories and choosing low-calorie, nutrient-dense foods. Average lean mass lost during weight loss: 35% - He states that about 35% of weight lost is lean body mass on average. Under 1,200 calories/day: Physician supervision recommended - He says very low-calorie diets should be medically supervised.

Pivotal Quotes: "The most common thing that holds people back is that many people have metabolic syndrome." — Dr. Kyle Gillette: Explaining why hormone optimization is usually secondary to foundational lifestyle and metabolic issues. "I truly believe that food is medicine, and the original medicines were all food and herb-based, anyway. And exercise is also medicine. Is sleep medicine? Is sunlight medicine? Yeah, I would say so." — Dr. Kyle Gillette: Summarizing his holistic view of lifestyle as therapeutic intervention. "Each human body is a machine, and just like you test a car coming off the assembly line... get a baseline lab panel with everything." — Dr. Kyle Gillette: One of his three final truths emphasizing screening and objective health data.

Implications: Listeners are encouraged to treat hormone health as a lifestyle outcome, not a standalone fix. The conversation pushes earlier screening, lifelong movement, better nutrition, and more openness about spiritual and emotional health in medicine.

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Lewis Howes is a New York Times best-selling author, 2x All-American athlete, keynote speaker, and entrepreneur. The School of Greatness shares inspiring interviews from the most successful people on the planet—world-renowned leaders in business, entertainment, sports, science, health, and literature—to inspire YOU to unlock your inner greatness and live your best life.

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