Peter Attia Drive
Peter Attia Drive

#73 - AMA #9: NAD & metformin, fat-burning zone, creatine, estrogenization of men, emergency kit for cold & flu, and more

In this "Ask Me Anything" (AMA) episode, Peter answers a wide range of questions from subscribers. Bob Kaplan, Peter's head of research, asks the questions. If you're not a subscriber and listening on a podcast player, you'll only be able to hear a preview of the AMA. If you

Featured Speakers

Peter Attia HostPeter Atiyah Guest

Topics Discussed

Episode Summary

Executive Summary: Peter Atiyah explains why his podcast avoids ads in favor of listener support, arguing that trust and authenticity are central to his mission. He then previews AMA #9, covering a wide-ranging conversation with Bob Kaplan that includes Atiyah’s near-join of Theranos, reflections on hindsight and delusion, and teaser topics like plastics, mental health, exercise, and creatine.

Main Topics: Why the podcast is listener-supported, not ad-supported: Atiyah argues that ads would undermine trust and make it harder to speak honestly about products; instead, he prefers a subscription model that funds the work while keeping the relationship with listeners transparent. Member benefits and exclusive content: He outlines what subscribers receive: enhanced show notes, downloadable transcripts, AMA access, and member-only discounts on products he already likes. Theranos origin story and near-employment: Atiyah recounts meeting Elizabeth Holmes in 2006, considering a role at Theranos, and ultimately declining because the science seemed uninteresting and the due diligence raised concerns. Hindsight bias and public judgment: He reflects on how easy it is to judge Theranos participants after the fact, emphasizing that hindsight bias distorts how people evaluate decisions made under uncertainty. Elizabeth Holmes, delusion, and accountability: Atiyah suggests Holmes may have believed she was doing good despite the deception, but stresses that delusion does not remove responsibility for wrongdoing. Preview of AMA #9 topics: The episode teaser lists several discussion areas: the estrogenation of men, plastics vs. glass containers, hunting trip takeaways, books, mental health advice, sick-day protocol, changing beliefs, fat-burning zone skepticism, and creatine.

Key Arguments: Trust is incompatible with paid product endorsements when the host is expected to recommend things sincerely. A subscription model preserves honesty because support comes directly from listeners rather than advertisers. Theranos did not appeal to Atiyah because the proposed testing platform seemed too limited to be clinically meaningful. Not joining Theranos was driven by opportunity cost, investor concerns, and scientific skepticism—not by knowledge of fraud. Public reactions to Theranos are shaped by hindsight bias; people overestimate how obvious the deception was before it collapsed. A person can be deeply delusional and still be morally accountable for harmful actions. Exclusive member content should provide value greater than the cost of support, including transcripts, show notes, AMAs, and discounts.

Data Points: Theranos employee count at first visit: 20–30 employees - Atiyah describes the company as a tiny startup when he first met Elizabeth Holmes in 2006. Theranos valuation in 2014: $9 billion - He cites the company’s valuation when reflecting on how much money he might have made had he joined. Time between first meeting and later reunion: 9 years - He met Holmes in 2006 and saw her again at a San Francisco event in 2015. Time between first meeting and later reunion: 8 years - He also frames the 2006-to-2014 period when Theranos became highly valued. AMA episode number: 9 - The episode is introduced as AMA number nine. Show notes staffing: 1 full-time person - Atiyah notes that a dedicated staff member now produces the show notes.

Pivotal Quotes: "I have a really hard time advocating for something that I'm not absolutely nuts for." — Peter Atiyah: Explaining why he avoids ad sponsorships and prefers only to recommend products he genuinely believes in. "I just thought it was the world's most uninteresting business in the history of civilization." — Peter Atiyah: Describing his skepticism about Theranos’s point-of-care blood testing concept. "I think Elizabeth felt that this was just a temporary speed bump along the way." — Peter Atiyah: Reflecting on Holmes’s likely mindset as the company’s problems were emerging.

Implications: The episode reinforces Atiyah’s brand as trust-first and subscriber-funded, while showing how scientific skepticism and hindsight shape judgments about high-profile startups. It also previews a broad AMA format built around practical health and performance questions.

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About Peter Attia Drive

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

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