This Week in Startups
This Week in Startups

Profound, Resistant AI & OpenAI’s Economic Pitch | E2071

Today’s show: Alex covers Mark Zuckerberg’s Joe Rogan interview, OpenAI’s economic pitch and the pending IPO of India’s Groww. Our guests include two companies freshly added to the TWIST500: James Cadwallader from Profound and Martin Rehak from Resistant AI. * Timestamps: (0:00) Alex kicks off the s

Featured Speakers

Jason Calacanis HostMark Zuckerberg GuestJames Cadwallader Guest

Topics Discussed

Episode Summary

Executive Summary: Alex analyzes Zuckerberg’s comments on Apple’s App Store and AI coding, then interviews founders of Twist 500 companies Profound and Resistant AI about how AI is reshaping search visibility and fraud detection. He closes with policy reactions to Biden’s chip-export rules, OpenAI’s pro-AI policy memo, and India’s strengthening IPO pipeline.

Main Topics: Mark Zuckerberg on Apple and AI coding (Priority: 5/5): Alex highlights two Rogan interview clips: Zuckerberg’s criticism of Apple’s App Store fees/rules and his prediction that AI will soon act like a mid-level engineer, writing substantial portions of code for Meta and other firms. Profound and the end of traditional SEO (Priority: 5/5): Profound’s CEO explains that AI search is creating a new visibility market where brands must optimize for answer engines like ChatGPT, Perplexity, Copilot, and Google AI Overviews rather than blue-link rankings. Resistant AI and the AI-vs-AI fraud arms race (Priority: 5/5): Resistant AI’s founder describes how criminals are using AI to improve document fraud, money laundering, and onboarding abuse, forcing defenders to use ensembles of smaller models and multi-signal detection. Biden administration chip-export restrictions (Priority: 4/5): Alex argues the new AI diffusion/export framework is widely disliked by Oracle, NVIDIA, and others because it could weaken U.S. competitiveness and shrink access to global chip markets. OpenAI’s U.S. AI policy agenda (Priority: 4/5): OpenAI’s policy plan emphasizes chips, data, energy, talent, politically neutral models, user data controls, AI economic zones, and federal preemption over fragmented state rules. India’s IPO market and Groww (Priority: 3/5): Alex notes India’s tech exit environment is improving, with Groww expected to go public in 2025 and multiple Indian startups lining up IPOs, signaling healthier liquidity outside the U.S.

Key Arguments: Apple’s App Store rules act like a tax on developers and may meaningfully suppress profit and viability for many companies. AI search is a platform shift: brands must now optimize for probabilistic, retrieval-based answer engines instead of deterministic SEO rankings. Traditional SEO strategies do not map cleanly onto AI answer engines because outputs are opaque, condensed, and sourced from many retrievals. Profound’s value lies in measuring and improving AI visibility through millions of prompts and search-conversation analytics. AI fraud is escalating because criminals now use AI to generate better fake documents, synthetic identities, and laundering operations at scale. Security vendors like Resistant AI can’t win by single-model detection alone; they need ensembles of models and weak-signal fusion across documents, behavior, and transactions. Biden’s chip rules are portrayed as overreaching and likely harmful to U.S. tech leadership, while OpenAI wants a lighter, more centralized federal policy regime. India appears to be a bright spot for tech IPOs, helping restore venture liquidity in a market where U.S. exits have been weak.

Data Points: Bitcoin intraday low: about $90,000 - Alex references a recent flash crash in Bitcoin after a strong run-up. Stablecoin market: doing exceptionally well - He notes U.S. dollar stablecoins remain healthy even as major crypto prices pull back. Profound funding: $3.5 million - The AI search visibility startup recently raised seed funding. Google search monthly users: roughly 3 billion unique monthly users - Profound estimates the scale of traditional search versus AI answer engines. AI answer engine monthly actives: about 600 million unique monthly actives - Estimate shared by Profound for AI-first search tools. ChatGPT weekly actives: 300 million weekly actives - Used as a benchmark for AI search/chat adoption. Profound enterprise commercial availability: since September/October 2024 - Founder says the product has been sold to big customers since late 2024. Resistant AI funding: about $30 million - The fraud-detection startup is backed by Index, GV, and others. Criminal business email compromise losses: about $10 billion per year in the US - Martin cites this as an example of large-scale fraud losses. Resistant AI growth: doubling to tripling every year - Founder says annual growth has been in this range since 2019. AI prompt volume: 2 million questions - Profound described running massive prompt sets to map AI search behavior. Profound customer timing: within about a week - Customers can get a visibility baseline quickly after onboarding. ChatGPT Deep Research sources: 73 sources - Alex cites an example of deep retrieval-based answers using many sources. Biden chip-rule market impact cited by Oracle: could shrink global market for US firms by 80% - Oracle criticizes the diffusion framework. Indian tech IPOs in 2024: 7 technology startups - TechCrunch says India had several public listings last year. Swiggy IPO size: $1.35 billion - Cited as the largest tech listing in the world in 2024. Indian startup IPO pipeline: more than 20 startups planned for 2025 - TechCrunch quote about expected listings. Groww expected valuation: $6 billion to $8 billion - Potential 2025 IPO valuation range mentioned for the Indian brokerage.

Pivotal Quotes: "if they didn't apply, like, I think, you know, it's like, and this is just meta. I think we'd like make twice as much profit or something." — Mark Zuckerberg: Zuckerberg criticizing Apple’s App Store rules and fees on the Joe Rogan podcast. "In 2025, we at Meta... are going to have an AI that can effectively be a sort of mid-level engineer that you have at your company that can write code." — Mark Zuckerberg: Zuckerberg forecasting near-term AI coding capability and broader automation of software work. "AI visibility is going to be a hair on fire priority for every company on the planet over the next year or two." — James Cadwallader: Profound’s CEO explaining why AI search optimization is becoming a new marketing imperative.

Implications: Expect marketing, security, and policy to be reorganized around AI-mediated systems: brands will compete for answer-engine visibility, fraud defenses will become AI-vs-AI, and governments will face pressure to simplify AI rules while preserving competitiveness.

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About This Week in Startups

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.

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