Episode Summary
Executive Summary: Lewis Howes interviews biochemist Jesse Inchauspé (“Glucose Goddess”) about how glucose spikes drive cravings, fatigue, inflammation, aging, and mental health symptoms. She argues for simple, non-restrictive habits—savory breakfasts, vinegar before carbs, veggie starters, and movement after meals—to reduce spikes, improve well-being, and make healthy eating sustainable without dieting.
Main Topics: Glucose spikes as a root cause of symptoms (Priority: 5/5): Inchauspé frames cravings, brain fog, fatigue, acne, sleep issues, and aging as signs of glucose spikes rather than isolated problems, urging listeners to see symptoms as body signals. Four core glucose hacks (Priority: 5/5): She explains her main methods: savory breakfast, vinegar before carbs, starting meals with vegetables, and moving after eating, all designed to reduce glucose spikes without restricting foods. Food, mental health, and trauma (Priority: 4/5): The conversation connects diet to mental health, including Inchauspé’s personal history of depersonalization after a spinal injury and how glucose monitoring helped her identify a food-mental health link. Freedom over dieting and body image (Priority: 4/5): Both hosts critique diet culture, body-shaming, and restrictive trends, arguing that food strategies should increase freedom, not anxiety, and that health should not be reduced to weight loss. Critique of fasting, trackers, and biohacking extremes (Priority: 3/5): Inchauspé says intermittent fasting and constant tracking are not necessary for health and can be stressful, especially for women, and that accessible habits are more sustainable than expensive wearables. Supplements and Anti-Spike (Priority: 3/5): She presents her supplement Anti-Spike as an optional tool for reducing meal spikes when vinegar or food-based hacks are impractical, emphasizing it should complement—not replace—core habits. Symptoms, medicine, and public health (Priority: 4/5): She warns against merely suppressing symptoms with medication and argues for addressing underlying causes through physiology-based education that is simple, practical, and widely accessible.
Key Arguments: Eating sugar after a meal as dessert creates less of a glucose spike than eating it on an empty stomach or at breakfast. Carbohydrates should be eaten with protein, fat, or fiber (“clothing on carbs”) to slow glucose absorption and reduce spikes. Vinegar before a carb-heavy meal can reduce the post-meal glucose spike by about 30%. Starting meals with vegetables/fiber creates a protective effect in the gut and lowers glucose absorption. A 10-minute walk or muscle use after eating helps muscles absorb glucose and reduces the impact of a meal. Frequent glucose spikes are linked to inflammation, faster aging (glycation), cravings, fatigue, and poorer sleep. Intermittent fasting is not required for health and may add unnecessary stress, particularly for women already under high stress. Weight loss is framed as a byproduct of metabolic balance rather than the primary goal; many people feel better even before weight changes. Mental health symptoms may be influenced by food and glucose dynamics; Inchauspé’s own depersonalization improved after identifying the food-spike connection. Supplements like Anti-Spike are positioned as support tools, not replacements, for core eating and movement habits.
Data Points: Vinegar effect on glucose spike: 30% reduction - One tablespoon of vinegar diluted in water before a carb-heavy meal Anti-Spike effect on glucose spike: 40% reduction - Taken before eating; claimed effect from clinical trials Natural GLP-1 increase from Anti-Spike: 15% increase - Reported after 6–12 weeks of use Movement after eating: 10 minutes - Recommended duration of walking or using muscles after one meal per day Glucose monitor usage: 2–3 years nearly nonstop - Inchauspé says she wore a glucose monitor continuously during her self-experimentation period Mental health symptom duration: 8 years - Depersonalization episodes persisted after her spinal injury until she connected them to food and stress Couples study sample: 100 couples - Study using voodoo dolls and glucose monitoring to examine relationship irritation and glucose variability Age claim: 85 years old - Humorous remark by Inchauspé about having no visible aging because she avoids glucose spikes Book experiment sample: 2,700 people - Referenced experiment showing many participants felt better and some lost weight while eating more Timing of glucose crash: About 90 minutes later - Described after a glucose spike from sugary breakfast Fasting glucose test frequency: Once a year - She recommends annual fasting glucose testing by a doctor Meal structure recommendation: 3 meals a day - Her preferred pattern when working and under stress, especially for women
Pivotal Quotes: "Symptoms are messages from your body." — Jesse Inchauspé: Core philosophy of the interview; she argues symptoms should be treated as signals, not silenced "Have a savory breakfast." — Jesse Inchauspé: One of her three final truths and a central practical recommendation throughout the conversation "Put clothing on your carbs." — Jesse Inchauspé: Her shorthand for pairing carbs with protein, fat, or fiber to reduce glucose spikes
Implications: The episode pushes listeners and the wellness industry toward simpler, physiology-based habits instead of restrictive diets or symptom suppression. It suggests better public health outcomes may come from accessible education, not expensive tracking or extreme trends.
About The School of Greatness
Lewis Howes is a New York Times best-selling author, 2x All-American athlete, keynote speaker, and entrepreneur. The School of Greatness shares inspiring interviews from the most successful people on the planet—world-renowned leaders in business, entertainment, sports, science, health, and literature—to inspire YOU to unlock your inner greatness and live your best life.