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Latent Space: The AI Engineer Podcast
Latent Space: The AI Engineer Podcast
220 episodes · Technology · by Latent.Space
About Latent Space: The AI Engineer Podcast
Latent Space: The AI Engineer Podcast is a Technology podcast with 220 episodes in the PodLexicon database, each accompanied by a full searchable transcript and AI-generated summary. The podcast by and for AI Engineers! In 2025, over 10 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0. We cover Foundation Models changing every domain in Code Generation, Multimodality, AI Agents, GPU Infra and more, directly from the founders, builders, and thinkers involved in pushing the cutting edge. Striving to give you both the definitive take on the Current Thing down to the first introduction to the tech you'll be using in the next 3 months! We break news and exclusive interviews from OpenAI, Anthropic, Gemini, Meta (Soumith Chintala), Sierra (Bret Taylor), tiny (George Hotz), Databricks/MosaicML (Jon Frankle), Modular (Chris Lattner), Answer.ai (Jeremy Howard), et al. Full show notes always on https://latent.space PodLexicon indexes every episode of Latent Space: The AI Engineer Podcast and turns each one into a searchable AI summary — find the episode that covers a topic, track how that topic evolved over time, or compare what different guests said about it.
Topics Covered on Latent Space: The AI Engineer Podcast
Memory and Persistent Context
Notable Guests on Latent Space: The AI Engineer Podcast
Recent Episodes
Simulation: the new Scaling Law — Joon Sung Park, Simile AI — August 21, 2026🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery — August 11, 2026The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten — August 03, 2026Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI — July 28, 2026Inside the Model Factory — Eiso Kant, Poolside AI — July 23, 2026🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist) — July 21, 2026🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences — July 16, 2026Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO — July 08, 2026🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI — July 01, 2026Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks — June 24, 2026Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan — June 22, 2026The Professor of Outputmaxxing — Anjney Midha, AMP — June 18, 2026🔬 The Self-Driving Lab — Joseph Krause, Radical AI — June 17, 2026Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs — June 04, 2026⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build — June 03, 2026🔬Scaling Past Informal AI - Carina Hong, Axiom Math — June 03, 2026GitHub's plan for Agents — Kyle Daigle, GitHub — June 02, 2026Why Video Agent models are next — Ethan He, xAI Grok Imagine — June 01, 2026The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray — May 28, 2026🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub — May 27, 2026Giving Agents Computers — Ivan Burazin, Daytona — May 21, 2026Railway: The Agent-Native Cloud — Jake Cooper — May 20, 2026The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion — May 18, 2026AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge — May 14, 2026🔬Doing Vibe Physics — Alex Lupsasca, OpenAI — May 05, 2026Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition — April 27, 2026AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026) — April 23, 2026Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO — April 22, 2026🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik — April 20, 2026Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion — April 15, 2026Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony — April 07, 2026Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different" — April 03, 2026Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun — April 02, 2026Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample — March 30, 2026🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik — March 24, 2026Dreamer: the Personal Agent OS — David Singleton — March 20, 2026Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop — March 17, 2026Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer — March 12, 2026NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo) — March 10, 2026Cursor's Third Era: Cloud Agents — March 06, 2026Every Agent Needs a Box — Aaron Levie, Box — March 05, 2026METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity — February 27, 2026[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka — February 26, 2026🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI — February 25, 2026Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis — February 24, 2026⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data — February 23, 2026Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z — February 19, 2026Owning the AI Pareto Frontier — Jeff Dean — February 12, 2026🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery — February 12, 2026The First Mechanistic Interpretability Frontier Lab — Myra Deng & Mark Bissell of Goodfire AI — February 06, 2026
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