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Latent Space: The AI Engineer Podcast
Latent Space: The AI Engineer Podcast
232 episodes · Technology · by Latent.Space
About Latent Space: The AI Engineer Podcast
Latent Space: The AI Engineer Podcast is a Technology podcast with 232 episodes in the PodLexicon database, each accompanied by a full searchable transcript and AI-generated summary. The podcast by and for AI Engineers! In 2025, over 10 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0. We cover Foundation Models changing every domain in Code Generation, Multimodality, AI Agents, GPU Infra and more, directly from the founders, builders, and thinkers involved in pushing the cutting edge. Striving to give you both the definitive take on the Current Thing down to the first introduction to the tech you'll be using in the next 3 months! We break news and exclusive interviews from OpenAI, Anthropic, Gemini, Meta (Soumith Chintala), Sierra (Bret Taylor), tiny (George Hotz), Databricks/MosaicML (Jon Frankle), Modular (Chris Lattner), Answer.ai (Jeremy Howard), et al. Full show notes always on https://latent.space PodLexicon indexes every episode of Latent Space: The AI Engineer Podcast and turns each one into a searchable AI summary — find the episode that covers a topic, track how that topic evolved over time, or compare what different guests said about it.
Topics Covered on Latent Space: The AI Engineer Podcast
End-to-End Inference Pipeline Optimization Speculative Decoding and Dedicated Deployments Production Readiness for New Models Structured Outputs and Tool Calling Reliability Parallelism and Hardware-Aware Scaling Quantization Trade-offs and Fidelity Preservation Future Modalities and Continual Learning MCP's rapid adoption and first-year recap
Notable Guests on Latent Space: The AI Engineer Podcast
Recent Episodes
Synthesis Superintelligence: from Semiconductors to Superconductors — Periodic Labs’ Liam Fedus and Ekin Dogus Cubuk — October 08, 2026Academia is for Ambition — Alex Zhang, MIT — October 02, 2026Why Dwarkesh is Wrong about Computer Use + How OpenAI shipped its Jev competitor in 1 Week — September 30, 2026Claude Code’s Next Era — Thariq Shihipar, Anthropic — September 29, 2026OpenRouter: from Seed to Stripe — with OpenRouter’s Alex Atallah & AMP’s Anjney Midha — September 25, 2026Runway’s WorldPrompt and the Engineering of Real-Time Worlds — September 25, 2026🔬Bio-security is an AI Arms Race - Eric Nguyen (CEO, Radical Numerics) — September 23, 2026🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science — September 22, 2026Jev: System One models for Prod, not God — with Diogo Almeida, CEO, TypeSafe AI — September 21, 2026Underwriting Superintelligence: Backing Agents you can Sue — Rune Kvist, AIUC — September 16, 2026Humanity’s Last Invention — Richard Socher of Recursive — September 14, 2026🔬“We have foundation models for language, not for physics” — Anima Anandkumar, Bren Professor of Computing — August 26, 2026Simulation: the new Scaling Law — Joon Sung Park, Simile AI — August 21, 2026🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery — August 11, 2026The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten — August 03, 2026Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI — July 28, 2026Inside the Model Factory — Eiso Kant, Poolside AI — July 23, 2026🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist) — July 21, 2026🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences — July 16, 2026Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO — July 08, 2026🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI — July 01, 2026Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks — June 24, 2026Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan — June 22, 2026The Professor of Outputmaxxing — Anjney Midha, AMP — June 18, 2026🔬 The Self-Driving Lab — Joseph Krause, Radical AI — June 17, 2026Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs — June 04, 2026🔬Scaling Past Informal AI - Carina Hong, Axiom Math — June 03, 2026⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build — June 03, 2026GitHub's plan for Agents — Kyle Daigle, GitHub — June 02, 2026Why Video Agent models are next — Ethan He, xAI Grok Imagine — June 01, 2026The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray — May 28, 2026🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub — May 27, 2026Giving Agents Computers — Ivan Burazin, Daytona — May 21, 2026Railway: The Agent-Native Cloud — Jake Cooper — May 20, 2026The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion — May 18, 2026AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge — May 14, 2026🔬Doing Vibe Physics — Alex Lupsasca, OpenAI — May 05, 2026Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition — April 27, 2026AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026) — April 23, 2026Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO — April 22, 2026🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik — April 20, 2026Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion — April 15, 2026Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony — April 07, 2026Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different" — April 03, 2026Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun — April 02, 2026Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample — March 30, 2026🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik — March 24, 2026Dreamer: the Personal Agent OS — David Singleton — March 20, 2026Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop — March 17, 2026Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer — March 12, 2026
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